Exposure to transforming growth factor β1 (TGFβ 1) or activin A has induced expression of SMC markers in ASCs. The vasculogenic characteristics of human ASCs in progenitor stage and after differentiation towards SMC phenotype were analysed in the present study.
How ASCs' SMC-lineage commitment affects their subsequent communication with ECs is unknown. In addition, ASCs differentiate towards the smooth muscle cell (SMC) phenotype under different stimuli, which prompted their use as a source of mural cells in fabricating small calibre vessels. Since its inception, Clayton Associates, FCA Venture Partners, and affiliates have invested over 100 venture deals, which has resulted in the creation of over 20,000 jobs and companies representing greater than $7B in annualized revenue.Adipose stromal cells (ASCs) support endothelial cell (EC) vasculogenesis through paracrine and cell-contact communications. Clayton Associates has two angel funds: Rolling Hills Ventures, which makes $500K to $1.5mm investments in companies beginning to gain traction, and Resolute Venture Partners, based out of Houston, TX. The firm makes seed investments through Bullpen Ventures, with investment sizes of $25K to $75K, to help companies get off the ground. Clayton Associates makes seed, angel, and venture stage investments in healthcare IT and technology companies. Typical investment sizes range from $2M to $6M of equity in companies with experienced management teams who are implementing proven business models with well-defined exit strategies. The firm's venture capital manager, FCA Venture Partners, has managed a total of 5 funds including exited funds FCA I and FCA II as well as three active funds FCA III, IV, and their new fund, FCA V. In 2005, Ingram Industries of Nashville, Tennessee made a minority investment in Clayton Associates and John R. Clayton Associates was founded in 1996 by R. Clayton Associates also manages Operating Companies, makes Angel Investments, and is actively involved in serving the Community.
Clayton Associates is the founding investor in three Venture Capital Funds: Altitude Ventures, FCA Venture Partners, and Resolute Venture Partners. The firm has built on its extensive operating experience and relationships to partner with entrepreneurs and help build successful businesses. Clayton Associates is the McWhorter family office.
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